Abstract

Typically, a specific organ or cell type is researched within the strict confines of vertebrate physiology. With the development of mouse genetics, which has revived the idea of a whole body study of physiology, this methodology has gradually transformed. Skeletal physiology is a striking illustration of how mouse genetics has significantly influenced our comprehension of physiology. According to a genetic approach to bone physiology, the chemical osteocalcin released by osteoblasts makes bone a real endocrine organ that controls male reproduction and energy consumption. A growing number of auxiliary organs are being connected to bone as a result of the on-going corpus of research that displaces bone from its conventional roles.

Keywords: Skeletal physiology, Osteocalcin receptor, metabolism.