Abstract

Malaria, a pervasive mosquito-borne disease caused by Plasmodium parasites, continues to be a significant global health burden. This article explores the complex relationship between malaria susceptibility and the diverse genetic backgrounds of human populations. Genetic factors play a crucial role in determining an individual's resistance or susceptibility to the disease, leading to considerable variability in malaria outcomes across different regions and populations. The abstract discusses the influence of genetic factors like hemoglobin variants, malaria resistance genes, and HLA variability on malaria susceptibility. It also highlights the microgeographic adaptations that have arisen in response to local malaria strains. By examining the impact of host genetic diversity on malaria susceptibility, this article underscores the importance of tailoring malaria control strategies and treatments to specific populations and regions.