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Hindi Research Article
Longitudinal Changes in Clinical Epidemiology and Drug Sensitivity of Community-associated Methicillin-Resistant Staphylococcus Aureus in a Tertiary Hospital in Japan
| Jun Taniguchi1,2, Masao Yoshinaga1,3*, Yu Kucho3, Mayuko Watanabe1,4 and Chiharu Kushida1,5 | ||
| 1Infection Control Team, Kagoshima City, Kagoshima, Japan | ||
| 2Department of Pharmacy, Kagoshima City, Kagoshima, Japan | ||
| 3Department of Pediatrics, Kagoshima City, Kagoshima, Japan | ||
| 4Department of Nursing, Kagoshima City, Kagoshima, Japan | ||
| 5Department of Clinical Laboratory, National Hospital Organization Kagoshima Medical Center, Kagoshima City, Kagoshima, 892-0853, Japan | ||
| Corresponding Author : | Masao Yoshinaga National Hospital Organization Kagoshima Medical Center Shiroyama-cho 8-1, Kagoshima 892-0853, Japan Tel: +81-99-223-1151 Fax: +81-99-223-7918 E-mail: m-yoshi@biscuit.ocn.ne.jp |
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| Received August 21, 2014; Accepted September 09, 2014; Published October 09, 2014 | ||
| Citation: Taniguchi J, Yoshinaga M, Kucho Y, Watanabe M, Kushida C (2014) Longitudinal Changes in Clinical Epidemiology and Drug Sensitivity of Communityassociated Methicillin-Resistant Staphylococcus aureus in a Tertiary Hospital in Japan. J Infect Dis Ther 2:172. doi: 10.4172/2332-0877.1000172 | ||
| Copyright: © 2014 Taniguchi J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
Related article at Pubmed Scholar Google |
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Abstract
Aim: The present study aimed to determine longitudinal changes in the background of patients with community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) and those in the susceptibility of CA-MRSA to antibiotics in a tertiary center.
Methods: The characteristics of MRSA isolates and patients between October 2005 and December 2011 were determined. This period was divided into two: the first half was from October 2005 to December 2008 and the second half was from January 2009 to December 2011. Data of age and sex of patients, and date and site of isolation were obtained. Antimicrobial susceptibility was examined for each period. Multiplex polymerase chain reaction methods were used to determine Staphylococcal cassette chromosome mec types and MRSA typing.
Results: A total of 513 MRSA isolates were identified. Of 265 and 248 MRSA strains in the first and second halves of the study period, 51 (19%) and 50 (20%) strains, respectively, were CA-MRSA. The prevalence of CAMRSA was highest in patients aged in the 80s and CA-MRSA was mainly isolated from the nose/pharynx. Antimicrobial resistance increased from the 2005-2008 to 2009-2011 periods for erythromycin (p=0.03), levofloxacin (p=0.003), imipenem (p=0.01), fosfomycin (p=0.02), and minocycline (p<0.001), but not for gentamicin, clindamycin, rifampicin, and vancomycin.
Conclusions: CA-MRSA accounts for 20% of total MRSA isolates in Japan. Ages of subjects with CA-MRSA and isolation sites have changed from the emerging stage to recent years. Antibiotic resistance has significantly increased in a tertiary hospital in Japan.
