ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • J Anal Bioanal Tech 2017, Vol 8(6): 387
  • DOI: 10.4172/2155-9872.1000387

Lack of Pharmacokinetic Interaction between Antipsychotics (Quetiapine, Clozapine and Olanzapine) and the Beta-Blockers Metoprolol, Propranolol, Bisoprolol and Nebivolol Except between Carvedilol and the Antipsychotics Quetiapine and Clozapine

Margarete Silva Gracia*, Regina Brandl and Ekkehard Haen
Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany
*Corresponding Author : Margarete Silva Gracia, Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, 93053 Regensburg, Germany, Tel: 0049- 9419434530, Fax: 0049-9419435832, Email: margarete.wolf@ukr.de

Received Date: Oct 24, 2017 / Accepted Date: Nov 03, 2017 / Published Date: Nov 06, 2017

Abstract

The purpose of this study was to evaluate a potential pharmacokinetic interaction between antipsychotics (quetiapine QUE, clozapine CLO and olanzapine OLA) and beta-blockers (metoprolol MET, propranolol PRO, bisoprolol BIS, nebivolol NEB and carvedilol CAR). Antipsychotics and beta-blockers are metabolized by the same cytochrome-P450 (CYP)-isoenzymes, which are inhibited by representatives of both substance classes. Pooled human liver microsomes (HLM) and recombinant CYP isoenzymes were used to determine whether the investigated antipsychotics and beta-blockers inhibit the metabolism of each other. Drug concentrations have been measured by high performance liquid chromatography (HPLC) with ultraviolet (UV) detection. Experiments with HLM showed that the metabolism of QUE as well as CLO slowed down in presence of CAR. There was no significant difference between the metabolism of the antipsychotics alone and the metabolism in combination with BIS, NEB and the two known CYP2D6-inhibitors MET and PRO. Experiments with recombinant CYP2D6 demonstrated an inhibitory effect on the metabolism of QUE and CLO by MET, PRO, NEB and CAR. The results suggest that CAR is also an inhibitor of other CYP enzymes, which are involved in the metabolism of CLO and QUE. It is assumed that CYP2D6 is a minor pathway of the antipsychotics and that the CYP2D6-inhibitory-effect of MET, PRO and NEB is compensated through a higher metabolism rate via the metabolic pathways of the other CYP-isoforms.

Keywords: High performance liquid chromatography; Pharmacokinetic; Antipsychotics; Metabolism

Citation: Gracia MS, Brandl R, Haen E (2017) Lack of Pharmacokinetic Interaction between Antipsychotics (Quetiapine, Clozapine and Olanzapine) and the Beta-Blockers Metoprolol, Propranolol, Bisoprolol and Nebivolol Except between Carvedilol and the Antipsychotics Quetiapine and Clozapine. J Anal Bioanal Tech 8: 387. Doi: 10.4172/2155-9872.1000387

Copyright: © 2017 Gracia MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top