Abstract

Protein conformational adjustments are activated techniques imperative for protein functions. Activation in a protein differs from activation in a small molecule in that it entails directed and systematic electricity flows thru favored channels encoded in the protein structure. Understanding the nature of these power glide channels and how electricity flows thru them for the duration of activation is quintessential for appreciation protein conformational changes. We these days [W. Li and A. Ma, J. Chem. Phys. 144, 114103 (2016)] developed a rigorous statistical mechanical framework for perception attainable power flows. Here, we whole this theoretical framework with a rigorous principle for kinetic strength flows: plausible and kinetic energies interconvert when impressed forces oppose inertial forces, whereas kinetic electricity transfers without delay from one coordinate to any other when inertial forces oppose every other.