Abstract

Recent studies shows how a new regulatory mechanism serves as an important biomarker for diabetes development as well as a possible therapeutic target for its prevention. The most significant pancreatic hormones in target tissues, such as the liver, are glucagon and insulin, which regulate proper glucose levels in response to food intake. Glucagon is secreted by pancreatic a-cells during fasting to increase blood glucose and protect the body from hypoglycemia. Glucagon has also been related to the development of diabetic hyperglycemia, primarily through the production of increased hepatic glucose, or HGP. Factor that affects transcription, glucagon acts by binding to a receptor known as a G-protein-coupled receptor, or GCGR.

Keywords: Biomakers; Diabetes