ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
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Jatropha tanjorensis Ameliorate Effects of Aspirin Induced Stomach UIcer in Wistar Rats

Umoren Elizabeth Bassey1*, Okon Idara Asuquo1, Brown Providence Idabie1, Owu Daniel Udofia2, Bassey Augustine Lawrence3 and Okon Effiom Eitm4
1Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers, Nigeria
2Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria
3Department of Pharmacology, PAMO University of Medical Sciences, Port Harcourt, Rivers, Nigeria
4Department of Biochemistry, PAMO University of Medical Sciences, Port Harcourt, Rivers, Nigeria
*Corresponding Author: Umoren Elizabeth Bassey, Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers, Nigeria, Tel: 8067709327, Email: lizzyumoren@yahoo.com

Received Date: Oct 30, 2022 / Published Date: Feb 16, 2023

Citation: Bassey UE, Asuquo OI, Idabie BP, Udofia OD, Lawrence BA, et al. (2023) Jatropha tanjorensis Ameliorate Effects of Aspirin Induced Stomach Ulcer in Wistar Rats. J Gastrointest Dig Syst 13: 732

Copyright: © 2023 Bassey UE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Jatropha tanjorens is considered a potential source of medicinal agents to treat different diseases. Aim: This study investigated the comparative effects of J. tanjorensis ethanolic leaves extract and amlodipine on gastro intestinal function in aspirin induced ulcer in wistar rats.

Methods: Wistar rats of both sexes (180 g-200 g) were divided into 6 groups (n=5). Group 1 received rat chow; group 2 received (5 mg/kg) of amlodipine orally. Group 3 received (200 mg/kg) of J. tanjorensis orally group 4 received aspirin only (250 mg/kg). Group 5 received (250 mg/kg) of Aspirin+Amlodipine (5 mg/kg). Group 6 received aspirin (250 mg/kg)+J. tanjorensis (200 mg/kg). After 14 days of treatment, animals were sacrificed and blood samples were collected for biochemical analysis while the stomach was harvested for histological analysis.

Results: Stomach acid secretion, gastric pepsin secretion and ulcer score all increased significantly (p<0.001) in the aspirin treated group as compared to other treatment group and control respectively. Aspirin significantly reduced adherent mucus secretion when compared to other treatment groups and control respectively at (p<0.05). When compared to control, ulcer score in Aspirin+Amlodipine and Aspirin+J. tanjorensis treated groups both showed significant increase (p<0.05). Aspirin treated animals showed decreased goblet cell with marked inflammation that was reversed by J. tanjorensis treatment. The results suggest that J. tanjorensis ameliorates aspirin induced stomach damage and that amlodipine treatment does not compromise the integrity of the stomach.

Conclusion: It is concluded that the leaves extract of J. tanjorensis ameliorated the effect of aspirin induced ulcer in Wistar rats; and that amlodipine does not adversely affect gastric secretion and predispose to gastric ulcer.

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