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Hindi Research Article
Isolation of New HexapeptidesâJBIR-39 and JBIR-40âfrom a Marine Sponge-Derived Streptomyces sp. Sp080513SC-24
Ikuko Kozone1, Miho Izumikawa1, Keiichiro Motohashi1, Aya Nagai1, Masahito Yoshida2, Takayuki Doi2, Motoki Takagi1* and Kazuo Shin-ya3*1Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan
2Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-aoba, Aramaki, Aobaku, Sendai 980-8578, Japan
3Biomedicinal Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan
- *Corresponding Authors:
- Dr. K Shin-ya
Biomedicinal Information Research Centre (BIRC)
National Institute of Advanced Industrial Science and Technology
(AIST), 2-4-7 Aomi, Koto-ku
Tokyo 135-0064, Japan
E-mail: k-shinya@aist.go.jp - Dr. M Takagi
Biomedicinal Information Research Centre (BIRC)
Japan Biological Informatics Consortium (JBIC)
2-4-7 Aomi, Koto-ku
Tokyo 135-0064, Japan
E-mail: motoki-takagi@aist.go.jp
Received date December 27, 2010; Accepted date February 15, 2011; Published date February 17, 2011
Citation: Kozone I, Izumikawa M, Motohashi K, Nagai A, Yoshida M, et al. (2011) Isolation of New Hexapeptides-JBIR-39 and JBIR-40 from a Marine Sponge- Derived Streptomyces sp. Sp080513SC-24. J Marine Sci Res Development 1:101. doi: 10.4172/2155-9910.1000101
Copyright: © 2011 Kozone I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Streptomyces sp. Sp080513SC-24 was isolated from a marine sponge, Haliclona sp., which is inhabited by diverse Actinobacteria , and then its culture was comprehensively searched for secondary metabolites. New two hexapeptides, JBIR-39 (1), and -40 (2), were isolated from the fermentation broth of Sp080513SC-24. The structures of 1 and 2 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses.
