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Is There Any Relationship between Apolipoprotein E Polymorphism and Idiopathic Parkinson's Disease?
Oh Dae Kwon*Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, South Korea
- *Corresponding Author:
- Oh Dae Kwon
Department of Neurology, Daegu Catholic University Medical Center
School of Medicine, Catholic University of Daegu
17- 33, Duryugongwon-ro, Namgu, Daegu
South Korea, 42472
Tel: +82 536504298
E-mail: dolbaeke@cu.ac.kr
Received date: November 22, 2016; Accepted date: December 26, 2016; Published date: January 02, 2017
Citation: Kwon OD (2016) Is There Any Relationship between Apolipoprotein E Polymorphism and Idiopathic Parkinson’s Disease? J Alzheimers Dis Parkinsonism 7:292. doi:10.4172/2161-0460.1000296
Copyright: © 2016 Kwon OD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Abstract
Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as in central nervous system. Among the three common alleles, the ε2 allele has the most stable structure followed by ε3 and ε4 in order. There is evidence for a deleterious role of apolipoprotein ε4 by atherosclerosis and amyloid beta accumulation in brain and body by the differences of three-dimensional structures among the apoE isoforms. APOE ε4 also seems to be related to cognitive decline in Parkinson’s disease but not too related to the age at onset of Parkinson’s disease.
