Abstract

Introduction: Metabolic syndrome (MS) is considered a possible risk factor for CRC, also because it affects bowel cleansing. As primary aim, association between MS or each parameter of MS and the prevalence and histology of precancerous colonic lesions (PCL) was examined. The secondary aim was to analyze the impact of these on bowel cleansing. precancerous colonic lesions (PCL) were examined.

Methods: In this observational single-center study, all consecutive outpatients, who underwent colonoscopy from May to September 2014, were enrolled. For statistical analysis, patients were collapsed into two groups according to the presence or absence of MS.

Results: 1257 patients were enrolled. MS was a risk factor for serrated lesions in the left colon (3% vs 1.2%; p=0.049). Analyzing MS parameters, only a higher BMI was associated with an increased risk of having an adenoma overall (25% for BMI >30), for colonic lesions in the left colon (RR 30%; p<0.01) and only for adenoma in the right colon (RR 30%; p<0.05). MS was inversely related with bowel cleansing overall and per-segments.

Conclusion: The presence of MS and obesity should be taken into consideration prescribing bowel preparation regimen and also for post-polypectomy surveillance, as these elements should be considered as aggravating cancer risk.

Keywords: Metabolic syndrome; Serrated polyp; Obesity; Colon cancer risk; Observational study; Bowel preparation