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Is Cellular Senescence Involved in Progressive Loss of Canals of Hering in Primary Biliary Cirrhosis?
Yuko Kakuda1, Kenichi Harada2* and Yasuni Nakanuma1,21Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan
2Department of Human Pathology, Kanazawa University School of Medical Sciences, Kanazawa, Japan
- *Corresponding Author:
- Kenichi Harada
Department of Human Pathology, Kanazawa University School of Medical Sciences
Kanazawa 9208640, Japan
Tel: 81 762645111
E-mail: kenichih@med.kanazawa-u.ac.jp
Received date: May 07, 2015; Accepted date: June 17, 2015; Published date: June 20, 2015
Citation: Kakuda Y, Harada K, and Nakanuma Y (2015) Is Cellular Senescence Involved in Progressive Loss of Canals of Hering in Primary Biliary Cirrhosis?. J Clin Exp Pathol 5:234. doi:10.4172/2161-0681.1000234
Copyright: © 2015 Kakuda Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Liver progenitor/stem cells (LPCs) play important roles for regeneration or replacement of hepatocytes and also cholangiocytes in some hepatobiliary diseases [1], and it has been reported that the LPCs activation is associated with a hepatic fibrosis and inflammation in several chronic liver diseases, such as chronic viral hepatitis and nonalcoholic steatohepatitis (NASH) [2,3]. Canals of Hering (CoH) are considered to be a niche of LPCs and they locate in between hepatocyte canaliculi and bile ductules.
