Abstract

Gene expression regulation and metabolism are essential processes that govern the functioning of living organisms. Recent research has uncovered a complex interplay between these two fundamental mechanisms. Gene expression regulation involves the precise control of gene activity, while metabolism encompasses the chemical reactions that convert nutrients into energy and cellular components. This article provides an abstract overview of the relationship between gene expression regulation and metabolism, highlighting their bidirectional influence on each other. Metabolites can act as signaling molecules that modulate gene expression, and gene expression can directly regulate metabolic pathways. Understanding this intricate interplay has significant implications for disease research and personalized medicine, as dysregulation of gene expression and metabolism often underlies complex diseases. Further investigation in this field promises to deepen our understanding of the coordination between gene expression regulation and metabolism, leading to innovative advancements in biology and medicine.

Keywords: Transcriptional regulation; Nutrient sensing; mTOR pathway; AMPK pathway; Complex diseases