Abstract

Neurodegenerative diseases represent a significant and growing global health burden, characterized by progressive loss of neuronal function and cell death. While the exact etiology of these disorders remains elusive, emerging evidence suggests that disruptions in proteostasis and ribostasis play pivotal roles in their pathogenesis. Proteostasis refers to the maintenance of protein homeostasis, ensuring proper protein folding, degradation, and clearance, while ribostasis involves the regulation of RNA dynamics, including synthesis, processing, and degradation. In this article, we explore the intricate interplay between proteostasis and ribostasis in neurodegenerative processes, shedding light on common mechanisms underlying disease progression. We discuss how perturbations in protein and RNA metabolism contribute to neuronal dysfunction and demise, and highlight potential therapeutic strategies aimed at restoring proteostasis and ribostasis to mitigate neurodegenerative pathology