Abstract

Background: Many studies have assessed the relation between IFN-γ +874(T/A) polymorphism and risk of aplastic anemia. However, the results of these studies were inconclusive. In the current study, we performed a metaanalysis to evaluate the association between IFN-γ +874(T/A) polymorphism and susceptibility to aplastic anemia.
Methods: All publications were searched precisely to find eligible articles on IFN-γ polymorphism +874(T/A) and aplastic anemia. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of association in the dominant model, recessive model, allelic model, homozygotes contrast, and heterozygotes contrast.
Results: A total of 4 case-control studies, including 210 cases and 537 healthy controls were elegble for this metta-analysis. Combined analysis of these studies showed no significant association between the IFN-γ polymorphism +874(T/A) and aplastic anemia risk in the overall population (dominant model: OR=1.52, 95% CI=0.57-2.46; recessive model: OR=1.27, 95% CI=0.47-2.08; allelic model: OR=0.98, 95% CI=0.63-1.34; TT vs. AA: OR=3.68, 95% CI=0.21-7.15, and AT vs. AA: OR=1.20, 95% CI=0.43-1.97). No heterogeneity or publication bias was observed in this study. Conclusion: This meta-analysis showed that the IFN-γ +874(T/A) polymorphism was not associated with the risk of aplastic anemia.To confirm our results, further studies are needed.

Keywords: IFN- γ, Polymorphism, Aplastic anemia, Meta-analysis