Abstract

Palliative care focuses on improving the quality of life for patients with life-limiting illnesses through effective symptom management. Histamine H3 receptors, primarily located in the central nervous system, play a pivotal role in regulating neurotransmitter release and influencing various CNS activities. This article explores the potential of H3 receptor modulators, such as antagonists and inverse agonists, in addressing key palliative care challenges, including pain, cognitive dysfunction, nausea, and sleep disorders. We discuss the integration of these modulators into palliative care through comprehensive symptom assessment, personalized treatment plans, multidisciplinary collaboration, and patient and caregiver education. While promising, the application of H3 receptor modulation in palliative care necessitates further clinical trials to establish efficacy and safety. By adopting these strategies, healthcare providers can enhance symptom management and improve the overall quality of life for palliative care patients.