Abstract

Substance addiction poses a significant public health challenge, necessitating innovative and effective treatment strategies. Intranasal insulin delivery has emerged as a promising therapeutic approach due to its potential neuroprotective and neuromodulatory effects. This article reviews the current understanding of intranasal insulin administration and its application in addiction treatment. The focus is on the pharmacokinetics, mechanisms of action, preclinical and clinical evidence, and potential therapeutic benefits. Intranasal insulin offers a novel, noninvasive, and potentially effective approach to mitigating addiction and its associated neurobiological consequences.