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Inorganic Polyphosphates: Jack of All Trades
| Tatiana Kulakovskaya* | |
| Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, 142290, Russia | |
| *Corresponding Author : | Tatiana V. Kulakovskaya Skryabin Institute of Biochemistry and Physiology of Microorganisms Russian Academy of Sciences Prospect Nauki, 5, Pushchino, 142290, Russia E-mail: alla@ibpm.pushchino.ru |
| Received July 02, 2012; Accepted July 02, 2012; Published July 05, 2012 | |
| Citation: Kulakovskaya T (2012) Inorganic Polyphosphates: Jack of All Trades. Biochem Physiol 1:e107. doi:10.4172/2168-9652.1000e107 | |
| Copyright: © 2012 Kulakovskaya T This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Prostate-Specific Antigen (PSA), a serine protease, is believed to regulate the actions of extracellular matrix proteins such as fibronectin and Insulin-like Growth Factor-Binding Proteins (IGFBPs), possible factors involved in tumor progression and metastasis. Two phosphonate ester derivatives Cbz-(4-AmPhGly)p(OPh)2 (Inh I) and Cbz- (4-AmPhe)p(OPh)2 (Inh II), first mechanism-based inhibitors for PSA were synthesized using Oleksyszyn oxidation reaction, and their inhibitory activities on cleaving fibronectin (both human and bovine) and IGFBPs were investigated. To elucidate the role of PSA in the development and progression of prostate cancer, the regulation of the PSA activity on these two physiological substrates was clearly illustrated by modulating the concentrations of inhibitors, i.e. cleavages of both fibronectin and IGFBPs by PSA are inhibited by structure specific designed diphenyl phosphonate esters, consistent with the putative degradation. The inhibition data of two synthetic phosphonate ester derivatives, as lead compounds, will facilitate the development of more specific inhibitors of PSA activity, likely to modulate the physiological control of the IGF in human prostatic cell growth.
