Abstract

Drug distribution studies are essential in pharmaceutical research to understand how drugs are distributed within the body post-administration. Traditional methods have been supplemented and enhanced by innovative approaches that leverage advanced imaging techniques, microdialysis, mass spectrometry imaging, computational modeling, and nano- and microscale drug delivery systems. These advancements offer detailed insights into drug localization, tissue penetration, and pharmacokinetic profiles, facilitating targeted drug delivery and personalized medicine. This review discusses the principles, applications, and future directions of these innovative approaches in drug distribution studies