Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats
Received Date: Dec 22, 2017 / Accepted Date: Jan 25, 2018 / Published Date: Feb 10, 2018
Abstract
We studied the effects of ACTH4-7 (the N-terminal fragment of the corresponding pituitary hormone molecule) on the pain-induced aggressive-defensive behavior in the foot-shock model in rats. The peptide was administered intraperitoneally in the saline at the doses 17, 50, 150 and 450 mcg/kg 12 min before the unavoidable painful stimulation of a pair of rats in an electrified camera. The analgesic and anti-aggressogenic effects of the peptide were found. These effects were significally enhanced after administration of the peptides synthesized by means of binding of the amino acids chain Pro-Gly-Pro to one or both ends of ACTH4-7 molecule. The data obtained increase the possibility of searching and using drugs to correct aggression.
Keywords: Regulatory peptides; ACTH4-7; Glyprolines; Pain; Aggression
Citation: Severyanova LA, Plotnikov DV (2018) Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats. J Bioterror Biodef 9: 160. Doi: 10.4172/2157-2526.1000160
Copyright: © 2018 Severyanova LA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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