Abstract

Mast cells (MCs) are bone marrow-derived tissue cells that contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity, autoimmunity, and psychiatric disorders. MCs located near the meninges communicate with microglia through the production of mediators such as histamine and tryptase, as well as the secretion of IL-1, IL-6 and TNF, inducing pathological changes in the brain. Preformed chemical inflammatory mediators and tumor necrosis factor (TNF) are rapidly released from the granules of MCs, the only immune cells that can store the cytokine TNF, but can also be generated later by mRNA. I have. The role of MCs in nervous system disorders has been extensively studied and reported in the scientific literature. This is of great clinical interest. However, many of the published articles refer to studies in animals (mainly rats or mice) rather than humans. MCs are known to interact with Neuromodulators that mediate endothelial cell activation. In the brain, MCs interact with neurons, causing neuronal excitability through the production of Neuromodulators and the release of inflammatory mediators such as cytokines and chemokines. This article examines the current understanding of MC activation by neuropeptide substance P (SP), corticotropin-releasing hormone (CRH), and neurotensin, and the role of proinflammatory cytokines.