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Inflammasomes in Cancer Caused by Inflammation

Peter James*
Department of Orthopaedic Surgery, Institute for Biomedical Engineering, Eberhard Karls University Tubingen, Tubingen, Germany
*Corresponding Author: Peter James, Institute for Biomedical Engineering, Eberhard Karls University Tubingen, Tubingen, Germany, Email: peter.j@gmail.com

Received Date: Jul 07, 2022 / Published Date: Aug 04, 2022

Citation: James P (2022) Inflammasomes in Cancer Caused by Inflammation. Immunol Curr Res, 6: 124.DOI: 10.4172/icr.1000124

Copyright: © 2022 James P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

An essential multiprotein complex known as the inflammasome is involved in inflammatory immunological responses. The autoactivation of caspase-1 and subsequent cleavage of proIL-1β and proIL-18, which are important sources of inflammatory symptoms, will occur as a result of inflammasome activation. On the other hand, inflammasomes also have anticancer properties through the regulation of the immune system and a specific type of programmed cell death known as pyroptosis. The final immunological effects are significantly influenced by the phases and compartments in which inflammasomes are activated. We provide a comprehensive overview of the roles played by inflammasomes in malignancies brought on by inflammation, particularly gastrointestinal and skin cancers. Additionally, information is provided about the inflammasome-related items' existing therapeutic uses and potential future research avenues [1].

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