Infection-Induced cAMP-Independent Regulation of Protein Kinase A (PKA)
Received Date: Dec 06, 2023 / Published Date: Jul 06, 2023
Abstract
The regulation of cellular signaling pathways is crucial for maintaining cellular equilibrium and coordinating responses to parasite infections. Protein Kinase A (PKA) is a key player in cellular signaling involved in regulating these processes. Apicomplexa parasites, including Plasmodium falciparum and Theileria annulata, exploit PKA to promote infection-induced pathogenesis. In this commentary, we describe two alternative
mechanisms employed by these medically important parasites to regulate Protein Kinase A (PKA) activity independent of fluxes in cyclic Adenosine Monophosphate (cAMP). Epigenetic regulation of PRKAR2B expression not only bypasses traditional cAMP-dependent regulation of PKA activity, but in doing so also provides new therapeutic targets for the potential treatment of malaria and tropical theileriosis.
Keywords: miR-34c; PRKAR2B; cAMP; Theileria; Plasmodium
Citation: Haidar M, Langsley G (2023) Infection-Induced cAMP-Independent Regulation of Protein Kinase A (PKA). J Infect Dis Ther 11: 554. Doi: 10.4172/2332-0877.1000554
Copyright: © 2023 Haidar M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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