Abstract

Gallbladder Cancer (GBC) is a rare but aggressive malignancy with marked ethnic and geographic variations. About 90% OF gallbladder cancers are Adenocarcinomas (AC) which are usually well to moderately differentiated. Adenosquamous/Squamous Cell Carcinoma (AS/SCC) of the gallbladder are a rare histopathologic subtype and account for nearly 1% to 12% of all GBC cases. The few cases in the literature suggest that these rare GBC tumors are more aggressive in comparison to adenocarcinoma and often infiltrate the adjacent viscera. Adenosquamous cell carcinoma shows a mixture of glandular and squamous elements with the squamous component between 25% and 99%. If the squamous component is less than 25%, the tumors are described as adenocarcinoma with focal squamous change. Pure squamous cell carcinoma is even rarer and is described in literature mainly in the form of case reports. These tumors exhibit exclusively squamous differentiation without any recognizable invasive glandular component.

Keywords: Gallbladder; Adenosquamous carcinoma; Cholelithiasis