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Hindi In vivo PKPD evaluation and computer modelling of apocynin in reducing organ superoxide production
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Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Oxidative stress due to the activation of Nox2-NADPH oxidase (Nox2) plays an important role in the pathogenesis of many diseases. Apocynin (4'-hydroxy-3'methoxyacetophenone) is an inhibitor of the Nox2 enzyme widely used in many preclinical and experimental studies. However, its in vivo pharmacokinetics and tissue distribution have not been well evaluated.
