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Hindi Research Article
In vivo Interaction Studies of ACE Inhibitors with NSAIDs on Carrageenan Induced Inflammation
| Safila Naveed1,3*, Najma Sultana2, Saeed Arayne M2, Rakhshinda Siddiqui4 and Moona Mehboob4 | |
| 1Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan | |
| 2United Biotechnologies, Karachi, Pakistan | |
| 3Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan | |
| 4CHK, Dow University Health Sciences, Karachi, Pakistan | |
| Corresponding Author : | Safila Naveed Research Institute of Pharmaceutical Sciences Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Karachi, Pakistan Tel: +0092-03002621917 Fax: +0092-36440171 E-mail: safila117@yahoo.com, safila117@gmail.com |
| Received February 18, 2013; Accepted March 27, 2013; Published March 29, 2013 | |
| Citation: Naveed S, Sultana N, Saeed Arayne M, Siddiqui R, Mehboob M (2013) In vivo Interaction Studies of ACE Inhibitors with NSAIDs on Carrageenan Induced Inflammation. Clinic Pharmacol Biopharm 2:108. doi:10.4172/2167-065X.1000108 | |
| Copyright: © 2013 Hari Krishna E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Both antihypertensive and non steroidal anti-inflammatory drugs are frequently prescribed together since hypertension and co-existing musculoskeletal problems are two of the frequent conditions. In vivo interaction studies of ACE inhibitors (enalapril, captopril and lisinopril) were carried out with commonly used NSAIDs (diclofenac sodium and mefenamic acid) in carrageenan induced inflammation in rats (CII) to check the anti-inflammatory response of NSAIDs in such cases. Edema rate and percentage reduction were calculated and data was analyzed by one way analysis of variance using SPSS INC. software. Tukey’s post-hoc test was conducted to determine group means differences taking significant level p<0.05 and p<0.005 highly significant.
