Abstract

This Center for International Blood and Marrow Transplant Research report describes the use of hematopoietic stem cell transplantation (HSCT) in pediatric cases with cancer, 4408 witnessing allogeneic (allo) and3076 witnessing autologous (bus) HSCT in the United States between 2008 and 2014. Leukemia was the most common suggestion for an allo- transplant (n = 4170; 94), and among these, acute lymphoblastic leukemia in alternate complete absolution (n = 829; 20) and acute myeloid leukemia in first complete absolution (n = 800; 19) werethe most common. The most constantly used patron relation, stem cell sources, and HLA match were unconnected patron (n = 2933; 67), bone gist (n = 2378; 54), and matched at8/8 HLA antigens (n = 1098; 37) independently. Neuroblastoma was the most common primary lump for a bus- transplant (n = 1338; 44). Tandem bus- transplants for neuroblastoma declined after 2012(40 in 2011, 25 in 2012, and 8 in 2014), whereas tandem bus- transplants increased for brain excrescences (57 in 2008 and 77 in 2014). Allo- transplants from cousins other than HLA-identical siblings doubled between 2008 and 2014 (3 in 2008 and 6 in 2014). These trends will be covered in unborn reports of transplant practices in the United States.