Abstract

A loss of kidney function causes metabolic acidosis in patients with chronic kidney disease (CKD). It has been  linked to CKD progression, mortality from all causes, and other negative outcomes. Our goal was to see if metabolic acidosis is linked to an increased risk of acute kidney injury (AKI).

Chronic kidney disease (CKD) is a prevalent and serious health condition characterized by the progressive deterioration of renal function. It affects individuals of all age groups and is associated with significant morbidity and mortality rates. CKD develops as a result of various underlying etiologies, including diabetes, hypertension, glomerulonephritis,and genetic disorders. The pathophysiology involves a complex interplay of inflammation, oxidative stress, fibrosis,and impaired renal function. CKD is associated with a wide range of complications, such as cardiovascular disease,mineral and bone disorders, anemia, and electrolyte imbalances. Early detection and management of CKD are crucialto slow theprogression of the disease, delay the onset of complications, and improve outcomes. The management of CKD involves a multidisciplinary approach, including lifestyle modifications, pharmacological interventions, and renal replacement therapy in advanced stages. Renal transplantation is considered the gold standard treatment for ESRD, offering the best long-term outcomes and improved quality of life. However, access to transplantation is limited, and many patients rely on dialysis for survival. CKD imposes a substantial burden on healthcare systems, emphasizing the importance of preventive strategies, early detection, and comprehensive management to reduce the global impact of CKD. Future research efforts should focus on identifying novel therapeutic targets, improving diagnostic techniques, and implementing effective strategies for CKD prevention and management.

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