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Hindi Research Article
Impairment of the Posterior Part of the Mirror Neurons System in Alzheimer's Disease: Evidence from EEG Biomarkers
Moretti DV1*, Paternicò D1, Binetti G1, Zanetti O1 and Frisoni GB1,2
1IRCCS S, Giovanni di Dio Fatebenefratelli, Brescia, Italy
2Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, USA
- Corresponding Author:
- Moretti Davide
Vito IRCCS S. Giovanni di Dio
Fatebenefratelli via Pilastroni
4 25125 Brescia, Italy
Tel: +393924737701
E-mail: davide.moretti@afar.it
Received date: March 10, 2014; Accepted date: April 30, 2014; Published date: May 30, 2014
Citation:Moretti DV, Paternicò D, Binetti G, Zanetti O, Frisoni GB (2014) Impairment of the Posterior Part of the Mirror Neurons System in Alzheimer’s Disease: Evidence from EEG Biomarkers. J Alzheimers Dis Parkinsonism 4:153. doi: 10.4172/2161-0460.1000153
Copyright: © 2014 Moretti DV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Mirror neurons have been localized in several locations, including the inferior parietal lobule (IPL). Increase of EEG alpha3/alpha2 frequency ratio has been detected in mild cognitive impairment (MCI) subjects who will convert in Alzheimer’s disease (AD). We investigated of the association of alpha3/alpha2 frequency ratio with cortical thickness in IPL in MCI. 74 adult subjects with MCI underwent EEG recording and high resolution MRI. Alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. Three MCI groups were obtained according to increasing tertile values of alpha3/alpha2 ratio. Difference of cortical thickness among the groups was estimated. High a3/2 group had wider cortical thinning than other groups, mapped on the IPL, Supramarginal and Precuneus bilaterally. High EEG alpha3/alpha2 frequency power ratio was associated with atrophy of IPL areas in MCI subjects. A link between AD and disrupture of mirror neurons system could be hypothesized.
