Abstract

It remains unclear whether the HLA haplotype of unconnected cord blood (UCB) should be matched to that of the case in single UCB transplantation. Therefore, using data from a Japanese registry, we anatomized the effect of haplotype matching on issues. Cases with hematologic conditions aged 16 times or aged who had experienced their first transplant were included (N = 1347). The goods of haplotype matching and high- frequence HLA haplotype on issues were anatomized. Median patient age was 55 times. The accretive frequentness of neutrophil engraftment among groups with 0, 1, and 2 HLA haplotype matches were 79, 82, and 88, independently( P = .008). In a multivariate analysis, the group with 0 haplotype matches was hardly associated with worse neutrophil engraftment (P = .087) and significantly associated with platelet engraftment (P = .044) compared with the group with 1 haplotype match. Twohaplotype matches were associated with a advanced threat of relapse. In the group with 1 haplotype match, the top 3 participated haplotypes were HLA haplotype matching might be considered to ameliorate engraftment. Two- haplotype matches should be avoided if the relapse threat is high. The haplotype itself may have an effect on the threat of acute graft- versus- host complaint and relapse.