Abstract

This study investigates the potential of a high-protein diet supplemented with excess leucine to prevent dormancyinduced insulin resistance in women. Dormancy, induced by periods of inactivity such as bed rest, often leads to metabolic disturbances including insulin resistance. Twenty-five healthy women underwent a 10-day bed rest protocol and were randomized to receive either a high-protein diet enriched with leucine or a control diet. Insulin sensitivity was assessed using oral glucose tolerance tests (OGTT) before and after bed rest. Results indicate that women on the high-protein diet with excess leucine maintained insulin sensitivity compared to controls (p <0.05). These findings suggest that dietary interventions targeting protein intake and leucine supplementation could be effective in mitigating dormancy-induced insulin resistance in women, potentially improving metabolic health during periods of inactivity.