Immunogenic and Protective Properties of Recombinant Proteins Based on Meningococcal Iga1 Protease
Received Date: Oct 07, 2015 / Accepted Date: Dec 08, 2015 / Published Date: Dec 15, 2015
Abstract
Recombinant proteins (M1K2–N963-LEH6, MA28–N963-LEH6 and ME135–H328-LEH6) have been created on the basis of the genome sequence of IgA1 protease of N. meningitidis serogroup B strain H44/76. It is revealed that, similarly to the native enzyme isolated earlier from N. meningitidis serogroup A strain A208, these proteins induce formation of animal protection against the infection with the virulent strain of meningococcus serogroup B. It is shown that these compounds are promising as a basis for a polyvalent anti-meningococcal vaccine.
Keywords: IgA1 protease; Recombinant proteins; Meningococcus; Immunogenicity; Protectivity
Citation: Zinchenko AA, Alliluev AP, Serova OP, Gordeeva EA, Zhigis LS, et al. (2015) Immunogenic and Protective Properties of Recombinant Proteins Based on Meningococcal Iga1 Protease. J Meningitis 1:102. Doi: 10.4172/2572-2050.1000102
Copyright: ©2015 Zinchenko AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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