Abstract

Immunogenetics, an interdisciplinary field at the nexus of immunology and genetics, investigates the genetic determinants influencing immune responses and disease susceptibility. This abstract provides an overview of the fundamentals of immunogenetics, highlighting the significance of the major histocompatibility complex (MHC) and human leukocyte antigen (HLA) system. Genetic polymorphisms impacting disease susceptibility, vaccination responses, and transplantation outcomes are explored. The article discusses the application of immunogenetics in personalized medicine, including tailored immunotherapies and precision vaccinology. Genomic approaches, such as genome-wide association studies (GWAS), contribute to a nuanced understanding of the genetic underpinnings of immune-related traits. Challenges in deciphering the complexity of immune responses and future directions in functional genomics are also addressed. Immunogenetics emerges as a cornerstone in the era of precision medicine, offering insights that reshape our approach to healthcare.