Human Leukocyte Antigen G as a Novel Target for Switch-based Chimeric Antigen Receptor Natural Killer Cell Therapy of Solid Cancer
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Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract
Challenges present with chimeric antigen receptors (CARs) adoptive cell therapy against solid tumors have been lacking a ubiquitous tumor-associated antigen across different tumor types, tumor antigen expression heterogeneity, and the immunosuppressive nonphysical tumor microenvironment. Thus, we developed a switch anti human leukocyte antigen (HLA)-G CAR that binds to HLA-G1~G7