Abstract

Background: Cancer antigen15-3 (CA15-3) is the most common tumor marker in breast cancer patients. The aim of the study analysis was to investigate the correlation, if there is any, of the levels of CA15-3 in patients with breast cancer and healthy females and to evaluate the efficacy of cancer associated antigen 15-3 (CA15-3) in monitoring breast cancer.
Methods: Clinical assessment was carried out in 40 serum samples. Female patient (n=20) were histologically verified of having breast cancer after chemical treatment and surgery. Healthy females subjects (n=20) with no history of breast cancer were included as controls. Enzyme linked immunosorbent assays was used for the quantitative determination of the cancer associate antigen.
Result: Elevation of CA15-3 levels was found associated with breast cancer patients. The serological levels were found around 75.04 ± SD/ mL (P=0.001), whereas the level among the control group was 13.99 ± SD/ mL).
Conclusion: CA15-3 concentration levels were found elevated in breast cancer patients with significant level demonstrating its diagnostic routine use.

Keywords: Breast cancer; Metastasis; Tumor; Chemotheray; Blood sample