ISSN: 2165-7386

Journal of Palliative Care & Medicine
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  • Editorial   
  • J Palliat Care Med 14: 644,

Harnessing Mitotic Catastrophe for Targeted Cancer Treatment

Giuliani Elli*
Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy
*Corresponding Author : Giuliani Elli, Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy, Email: giulianielli@gmail.com

Received Date: May 02, 2024 / Published Date: May 29, 2024

Abstract

Mitotic catastrophe is a mechanism of cell death that occurs during mitosis when cells experience severe mitotic stress, often due to DNA damage, defective spindle assembly, or improper chromosome segregation. In the context of cancer, the high rate of mitotic errors makes cancer cells particularly susceptible to mitotic catastrophe. This article explores the role of mitotic catastrophe in cancer therapy and the strategies to harness it for targeted cancer treatment. Microtubule-targeting agents, DNA-damaging agents, checkpoint inhibitors, and Aurora kinase inhibitors are some of the therapeutic agents that can induce mitotic catastrophe in cancer cells. By selectively targeting cancer cells, these agents offer the potential to improve therapeutic outcomes while minimizing harm to normal tissues. However, challenges such as selective targeting, resistance mechanisms, and the identification of biomarkers for response need to be addressed for the successful implementation of these treatments. This approach represents a promising frontier in cancer therapy, with the potential to revolutionize treatment protocols and enhance patient outcomes.

Citation: Elli G (2024) Harnessing Mitotic Catastrophe for Targeted CancerTreatment. J Palliat Care Med 14: 644.

Copyright: © 2024 Elli G. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.

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