Abstract

The gut microbiome, a complex ecosystem of microorganisms residing in the gastrointestinal tract, plays a pivotal role in human health and disease. Emerging evidence suggests that dysbiosis, or imbalance in the gut microbiota composition, is associated with the pathogenesis of various metabolic disorders, including diabetes mellitus. This article explores the potential of gut microbiome manipulation as a novel approach for diabetes prevention. We discuss the impact of gut dysbiosis on metabolic homeostasis, mechanisms by which the gut microbiome influences glucose metabolism, and strategies for modulating the gut microbiota to mitigate diabetes risk. Targeted interventions such as dietary modifications, probiotics, prebiotics, and fecal microbiota transplantation hold promise for restoring gut microbiome balance and preventing the onset of diabetes. However, challenges such as variability in individual response, long-term efficacy, and safety considerations must be addressed. Future research efforts should focus on elucidating the underlying mechanisms of gut microbiome-mediated effects on diabetes risk and optimizing personalized interventions for diabetes prevention.