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Hindi Grape seeds effect against den induced liver cancer
*Corresponding Author:
Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
This study was conducted to assess the anti-tumour properties of grapeseed extract (GSE) against chemically-induced liver cancer. Administration of different doses of GSE significantly inhibited foci formation as well as decreasing the number and the area of placental glutathione-S-transferase in livers of tumour-induced rats by approximately 4 and 10-fold deductions, respectively. The extract also induced apoptosis and down regulated histone deacetylase activity and inflammation makers, such as cyclooxygenase 2, and inducible nitric oxide synthase expressions in liver. It also induced differential cell cycle arrests and decreased the viability of HepG2 cells and induced early and late apoptosis through activating caspase-3 and Bax.
