Abstract

Forsythin, a bioactive constituent found in various plants, has attracted attention for its diverse pharmacological properties. This article provides a comprehensive review of the genetic toxicology and safety pharmacological evaluation of Forsythin, with a focus on its potential benefits and safety considerations. Genetic toxicology studies, including in vitro and in vivo experiments, consistently demonstrate no significant genotoxic effects of Forsythin, indicating its safety in terms of DNA damage or mutations. Safety pharmacology evaluations reveal that Forsythin does not exert adverse effects on vital physiological systems such as cardiovascular, respiratory, central nervous, and gastrointestinal systems. Preliminary pharmacokinetic studies indicate favorable absorption, distribution, metabolism, and excretion characteristics of Forsythin, supporting its potential bioavailability and therapeutic effectiveness. Preclinical studies have shown promising pharmacological activities, including antioxidant, anti-inflammatory, antiviral, hepatoprotective, and anticancer properties. Additionally, Forsythin exhibits immunomodulatory effects and neuroprotective potential. However, further clinical trials are necessary to determine its efficacy, optimal dosage, and long-term safety in humans. Comprehensive clinical investigations should also consider potential drug interactions, allergic reactions, and evaluate Forsythin's safety profile. Forsythin represents an intriguing natural compound with significant therapeutic potential, warranting further research in this field.