Abstract

Gene editing technologies, particularly CRISPR-Cas systems, have revolutionized molecular biology and therapeutic approaches. However, effective delivery of CRISPR components into target cells remains a significant challenge. Biomaterials play a pivotal role in developing efficient and safe delivery systems, enhancing the stability, targeting, and release of CRISPR constructs. This review explores various biomaterial platforms, including liposomes, polymers, and nanoparticles, highlighting their mechanisms of action and potential applications in gene therapy. By integrating advances in biomaterials with CRISPR technology, we can improve the precision and efficacy of gene editing, paving the way for novel therapeutic strategies