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Hindi Research Article
Frequency of APOE, ACE, MTHFR an CCR5 Polymorphisms in Patients with Mild Cognitive Impairment in Costa Rican Population
Norbel Román1,2*, Carolina Boza1,2,3, Leonardo Calvo3and Andrés Flores31Memory and Aging Clinic, Hospital San Juan de Dios, USA
2Neurology Department, Hospital San Juan de Dios, USA
3Hematology Research Center (CIHATA), University of Costa Rica, USA
- *Corresponding Author:
- Norbel Román
Neurology Department
Hospital San Juan de Dios, USA
Tel: 50688374214
E-mail: drnorbelroman@racsa.co.cr
Received date: October 10, 2016; Accepted date: November 15, 2016; Published date: November 22, 2016
Citation: Román N, Boza C, Calvo L, Flores A (2016) Frequency of APOE, ACE, MTHFR an CCR5 Polymorphisms in Patients with Mild Cognitive Impairment in Costa Rican Population. J Alzheimers Dis Parkinsonism 6:286. doi: 10.4172/2161-0460.1000286
Copyright: © 2016 Román N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: This is a descriptive cross-sectional epidemiological study describing the prevalence of polymorphisms within the Apolipoprotein E (ApoE), Methylenetetrahydrofolate reductase (MTHFR), Angiotensin converting enzyme (ACE), and Chemokine receptor 5 (CCR5) genes in patients with mild-cognitive impairment (MCI). Methods: The study analyzed 84 blood samples from patients diagnosed with MCI at the Memory and Aging Clinic at the Hospital San Juan de Dios in Costa Rica. The authors performed genetic analysis to determine and compare the genotypic and allelic frequencies in the MCI patients versus those reported for the Costa Rican population. Results: Genotypic and allelic frequencies obtained were compared to reports in Costa Rican population, and a gender-based analysis. There was significant difference in the APOE and MTHFR polymorphism (p=0.007446 and p=0.003329, respectively). Discussion: The study found a statistical difference in prevalence of the ApoE (ε2, ε3, ε4 alleles) and MTHFR (C677T) polymorphisms in the MCI patients. The study lacks a cohort of age-matched control subjects that do not have MCI. However, this study is very relevant to our understanding the role played by these genes in the etiopathogenesis of MCI.
