Abstract

The aim of present work was to develop and evaluate the floating tablets of Paliperidone. The effect of polymer concentration and type of polymer were examined. The floating drug delivery system (tablets) was prepared by direct compression method using Gum Copal, Isapgol husk and Fenugreek extract as polymer and sodium bicarbonates as gas generating agent. All formulations were evaluated for the pre compression and post compression, In vitro buoyancy and In vitro dissolution studies. Pre-compression studies revealed that there was no sign of any interaction between drug and polymers and all formulation showed good flow properties. Results of post compression parameters were found within the limits for all formulations. Among all the formulation F6 showed better buoyancy and drug release profile. The release of drug from the prepared formulations (F6) was found to follow zero order. It was concluded that drug release rate was increased as the concentration of polymer decreased. Isapgol husk showed greater drug release rate as compared to Gum Copal and Fenugreek extract.