Abstract

Purpose: The intermittent seizures of pediatric medicine- resistant epilepsy (DRE) are known to vitiate brain development and can lead to a loss in cognitive functioning. This study investigates the pre- and postoperative cognitive function in a pediatric epilepsy surgery cohort as well as prophetic determinants of change in intelligence quotient (Command) following surgery.

Methods: A successive series of 91 Danish children who passed focal resective epilepsy surgery between January 1996 and December 2016 were included. All passed preoperative cognitive evaluation and were reconsidered at 1- time and/ or 2- time follow- up. Single- operated andmulti-operated cases were examined independently.

Results: 79 of 91 cases were single- operated. Single- operated cases entered lessanti-epileptic medicines (AED) and endured a drop in seizure frequence postoperatively. 001. IQ increased postoperatively (IQ change ± standard divagation3.3 ±14.0),p. 05. High preoperative seizure frequence was a significant predictor for dropped Command, p.01. Multi-operated cases didn't witness a reduction in AED treatment. Surgery and continued AED treatment did, still, affect in significantly better seizure control. 01. IQ remained unchanged inmulti-operated cases.

Conclusion: Epilepsy surgery allowed for IQ earnings in single- operated cases. Preoperative seizure frequence was a significant predictor of IQ change following surgery. Relations between other, not included, possible predictors remain to be examined. Single- operated cases had the stylish cognitive outgrowth. The addition of anon-surgical control group is demanded to assess the extent of the salutary goods of surgery on cognitive capability [1].