Fluorescent Pore-Former Suggests an Approach for the Enhancement of Antibiotic Efficacy
Received Date: Sep 03, 2013 / Accepted Date: Sep 27, 2013 / Published Date: Oct 08, 2013
Abstract
A hydraphile channel having fluorescent dansyl side chains inserts into bacterial bilayers. The combination of nontoxic concentrations of hydraphiles and erythromycin enhances the efficacy of this antibiotic against Gram negative E. coli and P. aeruginosa.
Keywords: Amphiphile; Antibiotic; Bacteria; Erythromycin; Hydraphile; Synthetic channel
Citation: Gokel GW, Curvey NS, Gokel MR, Lindsey Meisel JW, Meisel JL, et al. (2013) Fluorescent Pore-Former Suggests an Approach for the Enhancement of Antibiotic Efficacy. Biosens J 2:103. Doi: 10.4172/2090-4967.1000103
Copyright: © 2013 Gokel GW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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