ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Research Article   
  • J Infect Dis Ther,

Findings on the Relationship between Cardiovascular Disease and Coronavirus Disease 2019: A Systematic Review

Yuri Henrique Da Silva1, José Gildo De Moura Monteiro Júnior2 and Rosângela Ferreira Frade De Araújo1,3*
1Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife-PE, Brazil
2Cardiologic Hospital of Pernambuco-PROCAPE/UPE, Recife-PE, Brazil
3Department of Biochemistry, Federal University of Pernambuco, Recife-PE, Brazil
*Corresponding Author : Rosângela Ferreira Frade De Araújo, Department of Biochemistry, Federal University of Pernambuco, Recife-PE, Brazil, Email: rfrade@prospecmol.org

Received Date: Feb 21, 2022 / Published Date: Apr 23, 2022

Abstract

Coronavirus disease 2019 (COVID-19) presents as the main cause of death, respiratory and heart failures, especially in the elderly, immunosuppressed, and those with cardiovascular comorbidities. Therefore, a better understanding of these findings is needed. A systematic review was carried out looking for articles published on the MEDLINE/PubMed using the following descriptors: ("cardiovascular disease") OR ("acute myocardial infarction") OR ("coronary artery disease") OR ("acute coronary syndrome") OR ("atherosclerosis") OR ("cardiac insufficiency") OR ("pericarditis") OR ("myocarditis") AND ("COVID-19") OR ("SARS-CoV-2") and considering inclusion and exclusion criteria. Of the total number of patients included in the 10 studies selected for this review, 40% of patients infected with SARS-CoV-2 had hypertension or other cardiovascular comorbidities, while 27% presented cardiovascular complications, mainly acute cardiac injury, arrhythmia, and heart failure. The hypotheses of involvement of an intense inflammatory response, decreased immunity and greater expression of ACE2 in the heart, associated with more severe heart conditions, were discussed in this study. The increase in cardiac and inflammatory markers was associated with worse clinical outcomes and risk of death, confirming the need to evaluate them since admission to the hospital. The articles analyzed presented as a limitation the small number of patients inserted, to the detriment of the pandemic state. We warned about the need for better clinical management of patients with cardiovascular comorbidities aiming at reducing the number of fatal cases due to infection.

Keywords: Cardiovascular disease; Novel coronavirus; SARS-CoV-2

Citation: da Silva YH, Monteiro Júnior JGM, de Araújo RFF (2022) Findings on the Relationship between Cardiovascular Disease and Coronavirus Disease 2019: A Systematic Review. J Infect Dis Ther S2:005.

Copyright: © 2022 da Silva YH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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