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Hindi Final Efficacy Results of a Randomized Phase II Study of Recombinant Interleukin-21 Compared to Decarbonize in Patients with Recurrent or Metastatic Melanoma
*Corresponding Author:
Copyright: © 2019 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract
Interleukin-21(IL-21) is a T-cell derived cytokine with antitumour activity
dependent on NK cells or CD8+ T cells. A previous phase II study demonstrated
an overall response rate (ORR) of 22.5% in previously untreated patients with
metastatic melanoma. We conducted a multi-centre randomized phase II study in
metastatic melanoma patients to evaluate the efficacy, toxicity, immunogenicity
and biomarkers associated with response to IL-21 versus dacarbazine (DTIC).
