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Fat-1 Transgenic Mice: An Endogenous N-3 Polyunsaturated Fatty Acids Mouse Model is used in AD Research
Xiang Gao1†, Yuhong Gan2†, Kefeng Wu2, Wende Li2,3* and Ren Huang3
1Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China
2Guangdong Key Laboratory for Research and Development of Natural Drug, Guangdong Medical College, Zhanjiang, Guangdong, China
3Guangdong Key Laboratory of Animal, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China
- *Corresponding Author:
- Wende Li
Guangdong Key Laboratory for Research and Development of Natural Drug
Guangdong Medical College, Zhanjiang, Guangdong, China
Tel: 0759-2230067
E-mail: lwd@gdlami.com
Received date September 18, 2016; Accepted date October 12, 2016; Published date October 19, 2016
Citation: Gao X, Gan Y, Wu K, Li W, Huang R (2016) Fat-1 Transgenic Mice: An Endogenous N-3 Polyunsaturated Fatty Acids Mouse Model is used in AD Research. J Alzheimers Dis Parkinsonism 6:272. doi:10.4172/2161-0460.1000272
Copyright: © 2016 Gao X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been wildly considered for positive effect of Alzheimer’s disease (AD). However, the intake of n-3 PUFAs is not encouraging to draw firm conclusion through preclinical and clinical research. The contribution of debate is derived from interference of dietary n-3 PUFAs, because of controlling the components and ratio of dietary PUFAs difficultly. In this context, transgenic fat-1 mouse that is capable of converting n-6 to n-3 fatty acids by feeding high n-6 PUFAs diet, leading to balance high n-3/n-6 PUFAs ratio, with increasing endogenous n-3 PUFAs and decreasing n-6 PUFAs in their organs and tissues. Thus, fat-1 mice is an ideal model to study the efficacy and mechanism of n-3 PUFAs in AD research, without the interference of the inevitable factors from dietary n-3 PUFAs. The fat-1 transgenic mice have become a useful tool for studying the potential benefit of endogenous n-3 PUFAs in behavior and neuromechanism of AD.
