Failure to develop Tolerance to Thyroid Peroxidase at an Early Age and a Strong Ctla-4 Gene Association Define Female-Dominated Type 1 Diabetes Subgroup
Received Date: Mar 02, 2023 / Published Date: Mar 30, 2023
Abstract
Type 1 diabetes and autoimmune thyroid disease (AITD) have been linked to HLA haplotypes with allelic variation of the T cell activation gene PTPN22 and the T cell regulatory gene CTLA4. We compare the relationship between these loci and type 1 diabetes patients with and without thyroid peroxidase autoantibodies (TPOAbs), an indicator of thyroid autoimmunity. People with type 1 diabetes from all over Great Britain had their TPOAbs measured. 67% were under the age of 18. Genotyping was done on these cases and controls from the same area.
Citation: Durrell P (2023) Failure to develop Tolerance to Thyroid Peroxidase at anEarly Age and a Strong Ctla-4 Gene Association Define Female-Dominated Type1 Diabetes Subgroup. J Clin Diabetes 7: 167.
Copyright: © 2023 Durrell P. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
Share This Article
Recommended Journals
Open Access Journals
Article Usage
- Total views: 897
- [From(publication date): 0-2023 - Jan 15, 2025]
- Breakdown by view type
- HTML page views: 817
- PDF downloads: 80
