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Hindi Research Article
Expression of P53 and P16 at Tumour Invasive Front in Oral Squamous Cell Carcinoma (OSCC)
Azizi SA1, Nik Mohd Abdul Nasser NFS1, Sailan AT2, Ajura AJ3 and Ibrahim N4*
2Department of Clinical Oral Biology, Faculty of Dentistry, The National University of Malaysia, Kuala Lumpur, Malaysia
3Stomatology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia
4Department of Oral Medicine and Oral Pathology, Faculty of Dentistry, The National University of Malaysia, Kuala Lumpur, Malaysia
- *Corresponding Author:
- Dr. Norliwati Ibrahim
BDS MClinDent
Lecturer at the Department of Oral Medicine and Oral Pathology
Faculty of Dentistry
Universiti Kebangsaan, Malaysia
Fax: +60392897798
Tel: +60392897998
E-mail: norliibrahim@gmail.com
Received: October 21, 2015 Accepted: January 27, 2016 Published: January 30, 2016
Citation: Azizi SA, Nik Mohd Abdul Nasser NFS, Sailan AT, Ajura AJ, Ibrahim N (2016) Expression of P53 and P16 at Tumour Invasive Front in Oral Squamous Cell Carcinoma (OSCC). Cosmetol & Oro Facial Surg 2:105. doi:10.4172/jcofs.1000105
Copyright: © 2016 Azizi SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Human papillomaviruses (HPV) tumorigenesis involves two major oncogenes, E6 and E7 of which E6 inactivates p53 while E7 indirectly leads to overexpression of p16.
Objectives: Correlation of expression of p53, p16 with clinicopathological and demographic parameters at tumour invasive front of oral squamous cell carcinoma (OSCC) were analyzed. Materials and Methods: Immunohistochemistry with p53 and p16 on paraffin embedded sections of 28 surgical cases of histopathologically confirmed OSCC and 10 biopsy cases of normal oral mucosa (NOM) was performed.
Results: p53 positivity was observed in 71.4% of OSCC with 32% showing strong intensity while only 20% of NOM were moderately positive (p=0.005). p16 expression was observed in 92.8% of OSCC with 50% showed strong intensity while 80% of NOM were positive with 60% showing strong intensity. Thus, the expression of p16 in OSCC and NOM is almost similar. No statistically significant difference was found between p53, p16 expressions and invasive front grading. However the intensity of p53 expression was significantly higher among Indians (p=0.03).
Conclusion: In oral mucosa, the p53 immunoexpression varies between cancerous or noncancerous tissue by mechanisms independent of p16 and we proposed that both expressions do not correlate with tumour cohesiveness.
