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Hindi Expression and Correlation Analysis of Related Molecules in Peripheral Blood of Patients with COVID-19
*Corresponding Author: Dehui Chen, Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Tel: 18928868216, Email: dehuichen2022@163.comReceived Date: Mar 11, 2024 / Published Date: Apr 12, 2024
Citation: Li H, Zhao L, Wu S, Tang S, Bahadur Kunwar K, et al. (2024) Expression and Correlation Analysis of Related Molecules in Peripheral Blood of Patients with COVID-19. J Infect Dis Ther S6:001.DOI: 10.4173/2332-0877.24.S6.001
Copyright: © 2024 Li H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Objective: To investigate the expression of neuropeptide family members in the peripheral blood of children infected with COVID-19 and its correlation with inflammatory indicators.
Methods: Blood samples were collected from 40 newly diagnosed children with COVID-19 infection and 17 hospitalized children with non- COVID-19 bronchial pneumonia in our hospital during the same period. Baseline clinical data were collected and analyzed. Expression and correlation analysis of neuropeptide-related molecules in peripheral blood were detected and analyzed by Enzyme-Linked Immunosorbent Assay (ELISA).
Results: In this study, 43% of COVID-19 patients are male. 71% of non-COVID-19 patients are male. ACE and ACE2 in the COVID-19 group were not significantly higher than that in the non-COVID-19 group, and ACE2 in non-COVID-19 and moderate COVID-19 groups was higher than that in severe groups (p=0.04*; p=0.03*). ASCL1 in the non-COVID-19 group was higher than that in the COVID-19 group (p=0.04*). ASCL1 in the non-COVID group was higher than that in the severe COVID group (P=0.02*). There were no significant differences in SP, VIP, and GRP between COVID-19 and non-COVID-19 groups. ASCL1 respectively with N% (r=-0.534, p<0.001***), CRP (r =-0.522, p<0.001***) negatively correlated, L% (r=0.572, p<0.001***), AST (r=0.496, p=0.001**) were positively correlated. There was no significant correlation with WBC count, PLT count, ALT, LDH.
Conclusion: In this study found that unlike adults, ACE and ACE2 were not high in children with COVID-19. ASCL1 in children with COVID-19 is lower than that in non-COVID-19 children, which may indicate that ASCL1 may be decreased in COVID-19 patients. At the same time, ASCL1 is negatively correlated with N% and CRP, suggesting that ASCL1 may play a certain role in COVID-19 inflammation.
