Abstract

Understanding the clinical metabolomics profile of cardiovascular physiology and disease provides valuable insights into the biochemical pathways and biomarkers involved in cardiovascular health. Metabolomics offers a comprehensive analysis of small molecule metabolites present in biological samples, reflecting the dynamic interactions between genetics, environment, and lifestyle factors. This review examines recent advancements in metabolomics technologies and their application in cardiovascular research. Key metabolites associated with cardiovascular diseases, such as coronary artery disease, heart failure, and hypertension, are discussed. Furthermore, the impact of metabolic pathways on disease pathogenesis, progression, and therapeutic strategies is explored. Metabolomics studies have identified potential biomarkers for early disease detection, prognosis, and treatment response assessment. Integrating metabolomics with other technologies and clinical data enhances our understanding of disease mechanisms and personalized medicine approaches. In conclusion, metabolomics offers a promising avenue for elucidating the complex metabolic networks underlying cardiovascular health and disease, paving the way for innovative diagnostic and therapeutic strategies in clinical practice.